Beneficial effects of adaptive servo ventilation in patients with chronic heart failure.
نویسندگان
چکیده
BACKGROUND Sleep-disordered breathing (SDB) is thought to be a state of inflammation caused by hypoxic stress. Whether adaptive servo ventilation (ASV) attenuates the inflammatory response and improves the cardiac function of patients with congestive heart failure (CHF) accompanied by SDB was not been investigated. METHODS AND RESULTS Seventeen inpatients with New York Heart Association (NYHA) II or III underwent polysomnography. There was a positive correlation between the apnea hypopnea index and high-sensitivity C-reactive protein (hs-CRP) level (r=0.753, P=0.016). The patients were divided into ASV (n=10) and non-ASV groups (n=7), and CHF-parameters were measured before and after ASV treatment. Improvement was noted for the NYHA class in the ASV group but not in the non-ASV group. In contrast to the non-ASV group, the level of brain natriuretic peptide (BNP), ejection fraction, and hs-CRP levels in the ASV group significantly improved (BNP, 212.1 ± 181.2 to 77.3 ± 54.0 pg/ml [P<0.05]; ejection fraction, 43.5 ± 6.4 to 53.3 ± 6.1% [P=0.002]; hs-CRP, 0.85 ± 0.58 to 0.21 ± 0.19 mg/dl, [P=0.008]). The increase in ejection fraction was correlated with a decrease in the hs-CRP level (r=-0.753, P=0.001). CONCLUSIONS Anti-inflammatory effects of ASV are important contributors for improving cardiac function in patients with CHF accompanied by SDB.
منابع مشابه
Adaptive servo ventilation for central sleep apnoea in heart failure: SERVE-HF on-treatment analysis
This on-treatment analysis was conducted to facilitate understanding of mechanisms underlying the increased risk of all-cause and cardiovascular mortality in heart failure patients with reduced ejection fraction and predominant central sleep apnoea randomised to adaptive servo ventilation versus the control group in the SERVE-HF trial.Time-dependent on-treatment analyses were conducted (unadjus...
متن کاملAdaptive Servo-Ventilation for Central Sleep Apnea in Systolic Heart Failure.
BACKGROUND Central sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects of adaptive servo-ventilation in patients who had h...
متن کاملIschemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failure.
1. Satake H, Sugimura K, Fukumoto Y, Fukuda K, Nakano M, Kondo M, et al. Effect of respiratory therapy on the prognosis of chronic heart failure patients complicated with sleep-disordered breathing: A pilot efficacy trial. Circ J 2016; 80: 130 – 138. 2. Momomura S, Seino Y, Kihara Y, Adachi H, Yasumura Y, Yokoyama H, et al; for the SAVIOR-C investigators. Adaptive servo-ventilation therapy for ...
متن کاملRationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure
AIMS Central sleep apnoea/Cheyne-Stokes respiration (CSA/CSR) is a risk factor for increased mortality and morbidity in heart failure (HF). Adaptive servo-ventilation (ASV) is a non-invasive ventilation modality for the treatment of CSA/CSR in patients with HF. METHODS SERVE-HF is a multinational, multicentre, randomized, parallel trial designed to assess the effects of addition of ASV (PaceW...
متن کاملSex matters in pulmonary arterial hypertension.
systolic heart failure and concomitant diastolic dysfunction: subanalysis of a randomized controlled trial. Respiration 2014; 87: 54–62. 3 Fietze I, Blau A, Glos M, et al. Bi-level positive pressure ventilation and adaptive servo ventilation in patients with heart failure and Cheyne-Stokes respiration. Sleep Med 2008; 9: 652–659. 4 Kasai T, Usui Y, Yoshioka T, et al. Effect of flow-triggered ad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation journal : official journal of the Japanese Circulation Society
دوره 74 10 شماره
صفحات -
تاریخ انتشار 2010